The Effect of Wet Cupping (Al-hijamah) and Limonene on Oxidative Stress and Biochemical Parameters in Diabetic Rats

Background: According to the international diabetes federation, 629 million adults will suffer from by 2045. Wet cupping therapy is a combination of bleeding and dry has been used in traditional medicine as complementary for diabetes. Limonene was shown have both antioxidant antidiabetic activity but its potential alongside other treatments not thoroughly explored. Objectives: Although wet-cupping widely under different conditions, treatment well-examined. Methods: Male Wistar rats were then injected with alloxan nicotinamide induce After cupping, rats’ serum nitric oxide, creatinine, SGPT, SGOT, cholesterol, triglyceride, glucose, GPX, urea, HDL levels determined. The glutathione, catalase, glutathione peroxidase, malondialdehyde, protein level serum, renal, liver measured. Results: results showed significant differences glucose among diabetic receiving wet limonene, limonene or compared rats, GSH control GPX catalase group. There no change NO, protein, triglyceride MDA, HDL, renal GSH, MDA Level. Conclusions: findings present study suggested that could be presented an agent lower elevated blood rats. Further clinical studies are required confirm findings.